ACTIONS

The mechanism of action of SINEQUAN (doxepin HCL) is not unquestionably known. It is not has the stimulant of central nervous system nor a monoamine oxidase the inhibitor. Current hypothesis is that clinical effects are owed, at least partly, to influence on adrénergique activity in him synapses so that the deactivation of norepinephrine by the reconsommation in the termini of nerve is told.
Studies of animal suggest that doxepin HCL does not upset the antihypertensive appreciably
action of guanethidine. In the animal study anticholinergic, antiserotonin and effects of antihistamine on the smooth muscle were shown. In higher that the ordinary clinical doses, the norepinephrine answer was potentiated in the animals. This effect was not shown in the human beings.
In clinical proportions until 150 mgs a day, SINEQUAN can be given to the concomitantly man with guanethidine and compounds attached without blocking the effect of antihypertensive. In proportions above 150 mgs a day blocking of the effect of antihypertensive of these compounds was announced.
SINEQUAN is practically devoid of euphoria as side effect. The characteristics of this type of
compound, SINEQUAN was not shown to produce physical tolerance or psychological
ependency visited addictifs compounds.